One of the most important things is to be able to do System Simulation on different directories/machines. The reasons are multiple:
It is a good idea to block a machine for System Simulation other than a personal Dorado. Personal Dorado are required to read the mail, program, makedo, and a thousand other things. With a simulation running, you can't rollback, gfi's are a problem, the machine is sluggish, and worst of all viewers locking happens frequently ...
If there is somewhere a reference version that simulates, and if the current version does not simulate, it might be useful to go back to the reference version and compare results or files.
The SSS responsability will have to be shared between several people.
Using several machines in parallel greatly accelerates the whole process.
Several people (ultimately all designers) will have to do system simulation.
When starting an overnight task, it is worth spending 10 minutes watching the beginning of the RollBackAnd to see if everything starts properly.
Keep a log of errors of changes, errors and fixes.